![]() May be contraindicated by maternal or fetal conditions. ![]() This includes short-term (i.e., ≤48 hours) prolongation of pregnancy to allow time for administration of antenatal corticosteroids corticosteroid administration prior to anticipated preterm birth is strongly associated with decreased neonatal morbidity and mortality.Īlso may be used for fetal neuroprotection prior to preterm delivery to reduce the risk of cerebral palsy †. ![]() However, efficacy and safety not established and not labeled by FDA for this use.ĪCOG and other experts support the short-term (≤48 hours) obstetric use of magnesium sulfate for appropriate conditions and durations of therapy. Has been used to inhibit uterine contractions in preterm labor (tocolysis) † and prolong gestation when considered beneficial. Used to correct or prevent hypomagnesemia in patients receiving total parenteral nutrition.Īlso used in the treatment of acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia usually, serum magnesium concentrations are below the lower limits of normal (1.5–2.5 or 3 mEq/L), and serum calcium concentrations are either normal (4.3–5.3 mEq/L) or elevated in such cases. Prevention and Treatment of Hypomagnesemia Has been used for immediate control of life-threatening seizures in children with acute nephritis. May be used parenterally to control seizures associated with epilepsy, glomerulonephritis, or hypothyroidism, since low plasma concentrations of magnesium may be a contributing cause of seizures in these conditions. Individualize decision to initiate therapy in these patients based on the presence of certain warning signs of seizures (e.g., headache, altered mental state, blurred vision, scotomata, clonus, right upper quadrant pain).Ĭlinical course of preeclampsia may change rapidly and unexpectedly monitor patients closely and initiate therapy if progression to severe preeclampsia occurs.ĪCOG strongly recommends administration of parenteral magnesium sulfate in patients with eclampsia continue therapy for ≥24 hours after last seizure. Routine use not recommended in women with preeclampsia without severe features (e.g., systolic BP ≥160 mm Hg or diastolic BP ≥110 mm Hg, thrombocytopenia, impaired liver or renal function, pulmonary edema, new-onset cerebral or visual disturbances). The American College of Obstetricians and Gynecologists (ACOG) strongly recommends intrapartum/postpartum use of magnesium sulfate in women with severe preeclampsia to prevent eclampsia. Generally considered anticonvulsant drug of choice for prevention and control of seizures in severe preeclampsia or in eclampsia appears to be more effective than phenytoin in preeclampsia, and more effective than phenytoin and diazepam in eclampsia. (See Preeclampsia and Eclampsia and also see Other Seizure Etiologies under Uses.) Preeclampsia and Eclampsia Used parenterally for prevention and control of seizures in toxemias (preeclampsia or eclampsia) of pregnancy and in various other conditions. Uses for Magnesium Sulfate Prevention and Control of Seizures Written by ASHP.Īnticonvulsant parenterally electrolyte required cofactor for numerous human enzyme systems. Drug class: Anticonvulsants, Miscellaneous
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